O&G Products - Hormones for HRT

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OESTROGEL


 OESTROGEL

Oestrogel is the first clear, transdermal estradiol gel therapy.

  • Significantly reduces the frequency and severity of moderate to severe vasomotor symptoms
  • Avoids first-pass hepatic metabolism
  • A measured-dose gel applied once daily
  • Easy adaptation and tailoring of the daily dose
  • A colourless, odorless gel that dries within two minutes
  • Does not drip or stick to fingers


PRESENTATION:

  1. Gel for percutaneous application

  2. 80gm tube with dosing plastic ruler

  3. One ruler equivalent to 1.5mg 17β- Estradiol

 

OESTROGEL ACTIVITIES:

  1. Controls the climacteric symptoms.

  2. No impairment of cardio-vascular risks.
          - Lipids.
          - Coagulation.
          - Blood pressure.




DOSAGE:

One ruler equivelant to 1.5mg 17β-estradiol (=2.5g gel)
On average, one ruler everyday, either 3 weeks out of 4 or 25 days per calender month. The effective dose may vary depending on individual needs related to personal pharmacokinetic particularities and the residual postmenopausal production of estrogen.

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                                                         UTROGESTAN



UTROGESTAN

Utrogestan = Micronized Natural Progesterone

  • Identical to endogenous progesterone
  • Micronized in oil
  • The ONLY progesterone capsule bioavailable via oral and vaginal route
  • The route of administration is determined by the indications.

Oral Administration Of Utrogestan Is Recommended For:

  • Menopause
  • Premenstrual Syndrome
  • Menace Of Preterm Delivery

Vaginal Administration Of Utrogestan Is Recommended (In Short-term Treatment) For:

  • Luteal Insufficiency (dysovulation, induced cycles, etc.)
  • Luteal Supplementation During Stimulated Cycles For IVF
  • Sterility By Ovarian Insufficiency (oocyte or embryo donation program)
  • Menace Of Early Abortion Or Prevention Of Recurrent Abortions By Documented Luteal Insufficiency

PRESENTATION:

  1. Capsule for oral and intravaginal administration.

  2. One capsule contains 100mg Natural Micronized Progesterone.

  3. Box of 30's capsules.


ACTIONS:

  1. Anti-estrogenic.

  2. Gestagen.

  3. Anti-androgenic.

  4. Anti-aldosterone.

  5. Tranquilizing effect (for oral administration only).



RECOMMENDED DOSAGES:

VAGINAL:

  1. Supplementation of the luteal phase during spontaneous or induced cycles (decreased fertility or primary/secondary infertility).

    200 mg/day for 10 days, starting from cycle day 17

  2. A.R.T. during IVF programs. 600mg/day (3x200 morning, noon and evening, starting from the evening of the day when transfer took place.)

  3. A.R.T. during egg donation programs.

    Days 13 and 14 of the transfer cycle: 1x100mg

    Days 15 - 25 of the cycle 100mg in the morning and evening

    From day 26 onwards, if conception has occurred, the dosage is increased at weekly intervals by 100mg/day, up to a maximum of 600mg/day, spread over three doses.

    This dosage is maintained up until day 60 of pregnancy.

  4. Threatened miscarriage - Prevention of repeated miscarriages due to a lack of progesterone.

    200 to 400 mg/day, divided into 2 doses.
This dosage is maintained up until week 12 of pregnancy.

ORAL:

  1. Menace or Premature delivery:
    Acute phase: 300 to 400 mg every 6 to 8 hours.

    Maintenance therapy up to the 36th week of pregnancy.

 


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         References: Please contact us for further information at mgnt@wellchem.com